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Статьи
Bioavailability study of a new amoxicillin tablet designed for several modes of oral administration
A new tablet of amoxicillin (Flemoxin solutab) has been formulated with galenic properties which allow it to be taken as a tablet, either swallowed, chewed or sucked, or to be taken after dispersion in water. This study was undertaken to compare the bioavailability of the new tablet (swallowed as such, or after dispersion) with a commercially available amoxicillin capsule and, for purposes of inte ...
Подробнее1163
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Статьи
Drug hepatotoxicity
Статься на английском языке. Drug toxicity is the leading cause of acute liver failure in the United States. Further understanding of hepatotoxicity is becoming increasingly important as more drugs come to market.
Подробнее906
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Статьи
Bacteriologic and clinical efficacy of amoxicillin/clavulanate vs. azithromycin in acute otitis media.
Статья на английском языке. A study was conducted to compare the bacteriological and clinical efficacy of amoxicillin/clavulanate and azithromycin in patients with acute otitis media (AOM), particularly the ability to eradicate the predominant AOM pathogens from middle ear fluid as assessed by mandatory second tympanocentesis. 238 infants and children with AOM were randomized to receive amoxici ...
Подробнее987
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Статьи
Clinical significance of antibiotic resistance in acute otitis media and implication of antibiotic treatment on carriage and spread of resistant organisms
Статься на английском языке. Acute otitis media (AOM) is the most common cause of antibiotic prescription in children in the developed world. In the presence of increasing resistance among the pathogens causing AOM, it is important to attempt to answer two related questions with regard to antibiotic treatment: Does the increasing antibiotic resistance among AOM pathogens cause an increase in bact ...
Подробнее1293
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Статьи
Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication
Статья на английском языке. When prescribing antibiotics for common indications, clinicians need information about both harms and benefits, information that is currently available only from observational studies. We quantified the common harms of the most frequently prescribed antibiotic, amoxicillin, from randomized placebo-controlled trials. ...
Подробнее909
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Статьи
Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media
Статья на английском языке. Use of a beta-lactamase stable antibiotic is called for in cases of acute otitis media (AOM) likely to be caused by betalactamase-producing Haemophilus influenzae or Moraxella catarrhalis. Two beta-lactamase-stable agents commonly used for empirical treatment of AOM are amoxicillin/clavulanate and cefixime. ...
Подробнее969
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Статьи
Randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: CLARICOR trial
Статья на английском языке. Short term clarithromycin in patients with stable coronary heart disease may cause significantly higher cardiovascular mortality. The long term safety of clarithromycin in patients with stable ischaemic heart disease should be examined.
Подробнее773
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Статьи
Hepatotoxicity of antibacterials: pathomechanisms and clinical data
Статья на английском языке. Drug-induced hepatotoxicity is a frequent cause of liverdisease and acute liver failure, particularly in patients treatedwith multiple drugs. Several antibacterial drugs have thepotential to cause severe liver injury and failure. This articleaims to increase the awareness and understanding of druginducedliver injury (DILI) due to antibacterial drugs. Itreviews the patt ...
Подробнее1000
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Статьи
Update on otitis media–prevention and treatment
Статья на английском языке. Acute otitis media and otitis media with effusion are common childhood disorders, a source of significant morbidity, and a leading cause of antibiotic prescription in primary health care. Although effective treatments are available, some shortcomings remain, and thus better treatments would be welcome. Recent discoveries within the field of otitis media research rela ...
Подробнее1420
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Статьи
Azithromycin and the risk of cardiovascular death
Статья на английском языке. Although several macrolide antibiotics are proarrhythmic and associated with an increased risk of sudden cardiac death, azithromycin is thought to have minimal cardiotoxicity. However, published reports of arrhythmias suggest that azithromycin may increase the risk of cardiovascular death.
Подробнее1123
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Статьи
Clinical practice guideline: adult sinusitis
Статья на английском языке. This guideline provides evidence-based recommendations on managing sinusitis, defined as symptomatic inflammation of the paranasal sinuses. Sinusitis affects 1 in 7 adults in the United States, resulting in about 31 million individuals diagnosed each year. Since sinusitis almost always involves the nasal cavity, the term rhinosinusitis is preferred. The guideline t ...
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Статьи
Clarithromycin for stable coronary heart disease increases all-cause and cardiovascular mortality and cerebrovascular morbidity over 10 years in the CLARICOR randomised, blinded clinical trial
Статья на английском языке. The CLARICOR trial reported that clarithromycin compared with placebo increased all-cause mortality in patients with stable coronary heart disease. This study investigates the effects of clarithromycin versus placebo during 10 years follow up.
Подробнее1088
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Статьи
Антибиотики в комплексной терапии бактериального риносинусита: возможности и ограничения
Вопросы диагностики и лечения воспалительных заболеваний околоносовых пазух (ОНП) являются одними из наиболее часто обсуждаемых в современной оториноларингологии. Это обусловлено несколькими хорошо известными обстоятельствами. Прежде всего, речь идет о необходимости и трудностях дифференциации наиболее вероятных возбудителей заболевания. На начальных этапах своего формирования абсолютное большинст ...
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Другое
Практическое руководство по антиинфекционной химиотерапии
Антиинфекционная химиотерапия представляет собой особую разновидность фармакотерапии, поскольку подразумевает использование антиинфекционных химиопрепаратов - уникальной группы ЛС, которые, наряду с вакцинацией, больше, чем какие-либо другие достижения науки, повлияли на продолжительность жизни человека. Причем это одна из наиболее динамичных групп лекарств, так как в связи с ростом резистентности ...
Подробнее1080
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Статьи
Лечение острых респираторных заболеваний у детей
Острые респираторные заболевания (ОРЗ) — большая группа инфекций, которые имеют много общего в патогенезе и путях передачи: речь идет в основном о воздушно-капельных инфекциях, хотя и контактный (через грязные руки) путь передачи играет не меньшую роль. Этим термином принято объединять острые неспецифические инфекции вне зависимости от их локализации — от ринита до пневмонии. Однако как клинически ...
Подробнее1232
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